Pyridoindole stobadine is a potent scavenger of hydroxyl radicals

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Pyridoindole stobadine is a nonselective inhibitor of voltage-operated ion channels in rat sensory neurons.

Pyridoindole stobadine, a compound with known neuroprotective, antioxidant, oxygen-free radical scavenging and antiarrhythmic properties, was analysed as to its effect on inward sodium and calcium currents (INa and ICa), respectively, and on fast inactivating and slow non-inactivating components of potassium outward current (IKf and IKs), respectively, in the neuronal membrane. A voltage-clamp ...

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 1991

ISSN: 0014-5793

DOI: 10.1016/0014-5793(91)81444-d